H.ImmunoScape, a biotechnology company focused on next-generation immunotherapies, today announced the appointment of John Tsang, Ph.D. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Identification of the docking site for CD3 on the T cell receptor beta chain by solution NMR. Crystal structure of a human CD3ed dimer in complex with a UCHT1 single-chain antibody fragment. Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling. Crystal structure of rhodopsin: a G-protein-coupled receptor. Masking of the CD3 gamma di-leucine-based motif by zeta is required for efficient T-cell receptor expression. Regulation of constitutive TCR internalization by the zeta-chain. Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Consequences for T cell antigen receptor assembly, processing, and expression. Failure to synthesize the CD3-gamma chain. The organizing principle in the formation of the T cell receptor-CD3 complex. A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation. The T cell receptor’s alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness. A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity. Positive selection through a motif in the alphabeta T cell receptor. Molecular architecture of the alphabeta T cell receptor-CD3 complex. Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling. Pre-T cell receptors (Pre-TCRs) leverage vbeta complementarity determining regions (CDRs) and hydrophobic patch in mechanosensing thymic self-ligands. The TCR C beta FG loop regulates alpha beta T cell development. Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop. Cell biology of T cell receptor expression and regulation. T cell receptor-MHC interactions up close. Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains. Structural basis of assembly of the human T cell receptor-CD3 complex. T cell antigen receptor recognition of antigen-presenting molecules. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. Crystal structure of the beta chain of a T cell antigen receptor. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Insights into the initiation of TCR signaling. TCR signaling: mechanisms of initiation and propagation. Mechanisms for T cell receptor triggering. Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Sykulev, Y., Joo, M., Vturina, I., Tsomides, T. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.
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